Senior Scientist Preformulation Particulate and Material Analysis

Profile

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as a technical expert and a scientific contributor. The Preformulation Senior Scientist within the Particulate and Material Analysis (P&MA) organization scientifically contributes to the successful development of new pharmaceutical products and drug delivery systems by focusing on material science, formulation development, physical characterization, and physical pharmaceutic activities during pre-formulation life-cycle processes.  With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project.

The Preformulation Senior Scientist is a R&D role that designs and carries out experiments required for the assessment of developability of API and excipients into a formulated product. The role supports PharmSci Small Molecule R&D with all forms of oral dosage and sterile injectables. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Follows QbD methodology and sound scientific principles to manage, design and carry out pre-formulation studies required for the assessment of developability of API into a formulated product, including solution/solid state characterization, solubility, excipient compatibility, polymorph characterization, particle size analysis, assessment of bulk properties of solids/semi-solids/liquids, maintaining quality/regulatory compliance for GxP environment.

• Documents, interprets, evaluates, communicates results of developmental work, and make recommendations for action.

• Prepares technical reports and verbal presentations on project progress and write specifications and standard operating procedures as needed.

• Investigates new technologies and novel analytical approaches to implement innovative problem solving strategies related to pre-formulation characterization.

• Facilitates cross-functional collaboration with Formulation, Analytical, Device, and early-stage development teams.

• Identifies and addresses continuous improvement processes

• Regularly contribute and influence at the project team level.

• Develop analytical methodologies and strategies needed to progress biotherapeutic products in the pipeline.

• Work directly with parties beyond Pfizer PharmSci/R&D, including but not limited to 3rd party analytical labs, Contract Manufacturing Organizations, and involvement with other divisions of Pfizer.

• Provide training, technical expertise and support to the analytical staff.

• Support formulation development, generate analytical data to be used for regulatory submissions, participate in technology transfer activities to manufacturing sites and provide formulation support in developing new products.

Qualifications

Must-Have

• Degree in pharmaceutical, chemistry, biomaterial, or a related field with pharmaceutical and technical experience: BS with 9 years of direct pre-formulation/physical characterization/materials science experience, MS with 7 years of direct pre-formulation/physical characterization/materials science experience, or Ph.D with <1 year of direct pre-formulation/physical characterization/materials science experience.
• Knowledge of traditional analytical techniques related to pre-formulation/physical characterization/materials science principles, including x-ray diffraction, DSC, Particle Size Distribution, Microscopy (OLM, SEM), powder flow, micromeritics, etc.
• Knowledge and application of scientific principles (organic chemistry, polymer chemistry, solid-state chemistry, pharmaceutics) and common processing techniques (tablets, capsules, suspensions, liquids, etc.) 
• Good verbal and technical writing skills.
• Good analytical and assessment skills, judgement, and problem-solving skills with the ability to adapt to changing priorities and deadlines
• Demonstrated ability and orientation toward analytical detail and scientific rigor.
• Ability to analyze complex datasets, trending data, and interpretation of compendia requirements.
• Strong oral and written communication skills; able to facilitate cross-functional collaboration and report out data in an easy-to-understand approach.
• Demonstrated project management and organizational skills; Able to manage concurrent projects.
• Ability to employ a logical, methodical approach in independently solving problems, developing solutions, and making recommendations.
• Strong MS Office skills

Nice-to-Have

• Previous experience in formulation development for semi-solids and oral solid dosage forms or processing pharmaceutical products preferred.

 
 

PHYSICAL/MENTAL REQUIREMENTS

• Standing or sitting for several hours. 
• Ability to occasionally lift 0 - 40 pounds. 
• Ability to analyze complex datasets, trending data, and interpretation of compendia requirements.
• Mathematical and reasoning ability
• Interpretation of application of SOPs
• Ability to work effectively on multiple projects with set deadlines

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

This position requires adherence to laboratory practices, including maintaining a clean environment (particle free) and wearing appropriate PPE for the task being performed.  Flexibility in schedule may be required to perform certain analyses, including adherence to timed studies.

OTHER JOB DETAILS

Eligible for Employee Referral Bonus

Relocation support available

#LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Research and Development

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Company info

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