Senior Research Associate Analytical Development Gene Therapy

Profile

**MEMBERS ONLY**SIGN UP NOW***. is building a robust, dynamic, and diverse network of manufacturing capabilities and collaborations – investing in innovation every step of the way. We are looking for a highly motivated Senior Research Associate to contribute to the Gene Therapy Analytical Development group with a focus on cell and molecular assays. Title will be commensurate with relevant experience in analytical development.

This researcher will:

• Help establish **MEMBERS ONLY**SIGN UP NOW***. as a leader in gene therapy analytical science by applying innovative processes, procedures and technologies in the development of best-in-class testing strategies

• Collaborate with analytical groups in other **MEMBERS ONLY**SIGN UP NOW***. Franchises to develop best practices and to further enhance a center of analytical excellence

Primary responsibilities include, but are not limited to, the following:

Job Responsibilities

• Work independently or under supervision of a senior scientist to develop and optimize analytical assays to support the Gene Therapy Franchise

• Independently conduct assays for both qualitative and quantitative analysis of proteins using a variety of molecular cell biology, biochemistry, or biophysical techniques

• Perform bioassays for determining product potency (vector transgene expression)

• Analyze data, record results into ELN/LIMS in a timely manner, and write technical reports summarizing data

• Formulate and test buffers and materials needed for routine assays

• Aseptic maintenance of cell cultures

• Assist in authoring SOPs, reports and other technical documents

Required Qualifications

• Bachelor's or Master's degree in analytical chemistry, biochemistry, molecular/cellular biology or related field

• Minimum 3+ (MS) or 5+ (BS) years of relevant experience

• Demonstrated ability to adhere to strict protocols and SOPs with accuracy and attention to detail

• Hands-on experience or exposure to cell biology and/or biochemical techniques, including:

• Mammalian adherent cell culture procedures and aseptic techniques

• Quantitative (RT-)qPCR, cell-based potency assays, and ELISA, HTRF, and/or plate based enzymatic assays

• Experience in working in an analytical development / process analytics setting

• Experience with data analysis tools and software packages such as GraphPad Prism, SAS JMP or PLA 3.0

• Working knowledge of multiparameter curve fitting, EC50 calculation using analytical software

• Strong desire to learn multiple techniques and willingness to provide support as required to meet team goals and deadlines

• Significant attention to detail and accuracy in following protocols

• Demonstrated ability to be highly productive in a fluid, fast-paced and teamwork environment

Preferred Qualifications

• Experience with digital PCR

• Experience in CMC-Development or GMP/QC setting

,identifier:{name:**MEMBERS ONLY**SIGN UP NOW***.,value:R-101824,@type:PropertyValue},datePosted:2022-03-02T06:43:56 00:00,validThrough:2022-04-01T04:00:00 00:00,employmentType:[FULL_TIME,OTHER],hiringOrganization:{name:**MEMBERS ONLY**SIGN UP NOW***.,@id:2463901,url:****MA,address:{addressCountry:US,addressLocality:Waltham,addressRegion:Massachusetts,@type:PostalAddress},@type:place},industry:Information Technology, Business/Data Analytics, Science/R&D, Biotherapeutics, Genetics,workHours:Full time,educationRequirements:Bachelors Degree,@type:JobPosting,@context:****

Company info

Sign Up Now - ChemistryCrossing.com